Histamine Release Induced by Human Leukocyte Lysates REABSORPTION OF PREVIOUSLY RELEASED HISTAMINE AFTER EXPOSURE TO CYCLIC AMP-ACTIVE AGENTS
نویسندگان
چکیده
منابع مشابه
Histamine release induced by human leukocyte lysates. Reabsorption of previously released histamine after exposure to cyclic amp-active agents.
The role of cyclic AMP in histamine release induced by human leukocyte lysates was investigated. Leukocytes were incubated with leukocyte lysates prepared by ultrasonic disruption, and histamine was determined fluorimetrically. Several cyclic AMP-active agents had a marked inhibitory effect on histamine release. Theophylline and isoproterenol produced 50% inhibition at concentrations of less th...
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The effects of metabolic inhibitors and carbohydrates on histamine release induced by human leukocyte lysates have been studied to gain an understanding of the mechanism of histamine release in this system. Dinitrophenol produced 80% inhibition of histamine release at a concentration of 10(-3) M. Iodoacetic acid inhibited release to a lesser extent, and deoxyglucose had relatively little effect...
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The characteristics of histamine release induced by human leukocyte lysates were determined. Intact human leukocytes released histamine during incubation with leukocyte lysates. Maximal release occurred under physiological conditions of temperature and pH, and both Ca(2+) and Mg(2+) were required. The addition of ethylenediaminetetraacetic acid abruptly inhibited release. Complement was not req...
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Purified human C3a and synthetic COOH-terminal peptides of C3a, i.e., a pentapeptide, Leu-Gly-Leu-Ala-Arg (5R), and an octapeptide, Ala-Ala-Ala-Leu-Gly-Leu-Ala-Arg (8R) induced histamine release from human basophil granulocytes. On a molar basis, 5R was one-tenth and 8R was one-fifth as active as C3a in causing histamine release. It was found that 125I-C3a binds to whole leukocytes, interacting...
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Histamine release by neuromuscular blocking agents Sir,—The design of the study by Naguib and colleagues [1] on the histamine releasing potencies of various neuromuscular blocking drugs resulted in cardiovascular changes which were profound, adverse and predictable. For example, the data sheet for mivacurium suggests administration over 5–15 s. The authors chose 5 s, despite quoting references ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1973
ISSN: 0021-9738
DOI: 10.1172/jci107365